#93 - Sleeping Pills and their Alternatives with Dr. Ranji Varghese
The Matt Walker Podcast - A podcast by Dr. Matt Walker - Luni
Matt Walker welcomes Dr. Ranji Varghese back to the podcast today to complete the whole sleeping pill story by discussing newer sleeping pills, beyond benzos and Z-drugs. Together, they explore Melatonin receptor agonists (like Ramelteon) that signal sleep preparation, unlike sedating GABAergics. They also detail how DORAs inhibit the wakefulness-promoting orexin, how off-label options (ex. trazodone, low-dose doxepin) affect histamine, the risks and benefits of each. Dr. Varghese goes ...
